Genetic composition and virulence of influenza virus: differences in facets of virulence in ferrets between two pairs of recombinants with RNA segments of the same parental origin.
Identifieur interne : 002640 ( Main/Exploration ); précédent : 002639; suivant : 002641Genetic composition and virulence of influenza virus: differences in facets of virulence in ferrets between two pairs of recombinants with RNA segments of the same parental origin.
Auteurs : D. Campbell ; C. Sweet ; A J Hay ; A. Douglas ; J J Skehel ; T J Mason ; H. SmithSource :
- The Journal of general virology [ 0022-1317 ] ; 1982.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Animaux, Antigènes viraux (génétique), Carnivora (microbiologie), Fièvre (étiologie), Furets (microbiologie), Gènes viraux, Infections à Orthomyxoviridae (microbiologie), Maladies pulmonaires (étiologie), Recombinaison génétique, Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité).
- MESH :
- génétique : ARN viral, Antigènes viraux, Virus de la grippe A.
- immunologie : Virus de la grippe A.
- microbiologie : Carnivora, Furets, Infections à Orthomyxoviridae.
- pathogénicité : Virus de la grippe A.
- étiologie : Fièvre, Maladies pulmonaires.
- Animaux, Gènes viraux, Recombinaison génétique.
English descriptors
- KwdEn :
- Animals, Antigens, Viral (genetics), Carnivora (microbiology), Ferrets (microbiology), Fever (etiology), Genes, Viral, Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (pathogenicity), Lung Diseases (etiology), Orthomyxoviridae Infections (microbiology), RNA, Viral (genetics), Recombination, Genetic.
- MESH :
- chemical , genetics : Antigens, Viral, RNA, Viral.
- etiology : Fever, Lung Diseases.
- genetics : Influenza A virus.
- immunology : Influenza A virus.
- microbiology : Carnivora, Ferrets, Orthomyxoviridae Infections.
- pathogenicity : Influenza A virus.
- Animals, Genes, Viral, Recombination, Genetic.
Abstract
Facets of virulence for ferrets of 16 recombinant clones of two parent viruses A/Finland/4/74 (H3N2) and A/Okuda/57 (H2N2) were determined and viewed in relation to their genetic composition. Of the five pairs of recombinant clones with RNA segments of the same parental origin, differences in facets of virulence were detected between members of two of the pairs. One pair differed in ability to produce fever, and another pair in ability to infect the lower respiratory tract. Subsequent analyses indicated slight differences in two genes of the first pair of viruses. Of all the recombinant clones examined the three that derived their surface antigens from the attenuated parent (A/Okuda) were less virulent than the 13 which possessed the surface antigens of the virulent parent (A/Finland). The virulence of the latter clones tended to decrease as the number of RNA segments that were derived from A/Okuda increased.
DOI: 10.1099/0022-1317-58-2-387
PubMed: 7061993
Affiliations:
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Le document en format XML
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<term>Fever (etiology)</term>
<term>Genes, Viral</term>
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<front><div type="abstract" xml:lang="en">Facets of virulence for ferrets of 16 recombinant clones of two parent viruses A/Finland/4/74 (H3N2) and A/Okuda/57 (H2N2) were determined and viewed in relation to their genetic composition. Of the five pairs of recombinant clones with RNA segments of the same parental origin, differences in facets of virulence were detected between members of two of the pairs. One pair differed in ability to produce fever, and another pair in ability to infect the lower respiratory tract. Subsequent analyses indicated slight differences in two genes of the first pair of viruses. Of all the recombinant clones examined the three that derived their surface antigens from the attenuated parent (A/Okuda) were less virulent than the 13 which possessed the surface antigens of the virulent parent (A/Finland). The virulence of the latter clones tended to decrease as the number of RNA segments that were derived from A/Okuda increased.</div>
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